222299-39-0Relevant academic research and scientific papers
Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2- α]benzimidazoles
Maryanoff, Bruce E.,Nortey, Samuel O.,McNally, James J.,Sanfilippo, Pauline J.,McComsey, David F.,Dubinsky, Barry,Shank, Richard P.,Reitz, Allen B.
, p. 1547 - 1552 (1999)
A variety of pyrido[1,2-α]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-fused derivative 7 exhibited potent activity, as did the 6- and 7-pyrido compounds 3 and 4.
Naphtho-imidazo pyridine derivatives useful in treating central nervous system disorders
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, (2008/06/13)
A compound of the general formula I: is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions, processes for preparing the compounds and methods of treatment are also disclosed.
