Bioorganic and Medicinal Chemistry Letters p. 1547 - 1552 (1999)
Update date:2022-08-04
Topics:
Maryanoff, Bruce E.
Nortey, Samuel O.
McNally, James J.
Sanfilippo, Pauline J.
McComsey, David F.
Dubinsky, Barry
Shank, Richard P.
Reitz, Allen B.
A variety of pyrido[1,2-α]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-fused derivative 7 exhibited potent activity, as did the 6- and 7-pyrido compounds 3 and 4.
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