222302-26-3Relevant academic research and scientific papers
Nucleophilic addition of organometallic reagents to N,N-dimethyl- and SAMP-glyoxal-monohydrazones
Cere, Vanda,Peri, Francesca,Pollicino, Salvatore,Ricci, Alfredo
, p. 1087 - 1098 (2007/10/03)
Nucleophilic addition of organometallics to N,N-dimethyl-glyoxal- monohydrazone occurs smoothly to give the corresponding α-hydroxy hydrazones in high yields. From these compounds, polyfunctional derivatives such as protected α-hydroxy aldehydes and α-hydroxy nitriles can be easily obtained in satisfactory to good yields. The addition to a SAMP-hydrazone proceeds with low (35% d.e.) or reasonable (60% d.e.) levels of stereoselectivity when vinylmagnesium reagents are employed.
