222306-38-9

Basic information

• Product Name: 5-bromo-1-ethyl-2-(4-fluorobenzoyl)-3-methyl-1H-indole
• Synonyms: 5-bromo-1-ethyl-2-(4-fluorobenzoyl)-3-methyl-1H-indole
• CAS NO: 222306-38-9
• Molecular Weight: 360.226
• Mol File: 222306-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-1-ethyl-2-(4-fluorobenzoyl)-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-ethyl-2-(4-fluorobenzoyl)-3-methyl-1H-indole(222306-38-9)
• EPA Substance Registry System: 5-bromo-1-ethyl-2-(4-fluorobenzoyl)-3-methyl-1H-indole(222306-38-9)

Safety Data

• Hazardous Substances Data: 222306-38-9(Hazardous Substances Data)

Upstream product

• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 
• 10075-50-0 5-bromo-1H-indole 
• 403-43-0 4-fluorobenzoyl chloride 
• 222306-37-8 5-bromo-1-ethyl-3-methyl-1H-indole 
• 10075-48-6 5-bromo-3-methyl-1H-indole 

Downstream Products

• 222306-39-0 5-bromo-1-ethyl-2-[(4-fluorophenyl)(hydroxy)methyl]-3-methyl-1H-indole 

Relevant articles and documents

New selective nonsteroidal aromatase inhibitors: Synthesis and inhibitory activity of 2, 3 or 5-(α-azolylbenzyl)-1H-indoles

Six azolyl substituted indoles were synthesized and tested for their activity to inhibit two P450 enzymes: P450 arom and P450 17α. It was observed that the introduction of α-imidazolylbenzyl chain at carbon 3 or 5 on indole nucleus led to very active molecules. Compounds 22, 23 and especially 33 demonstrate very high potential against P450 arom. Under our assay conditions of high substrate concentration the IC50 are 0.057, 0.0785 and 0.041 μM, respectively. These compounds are moderate inhibitors against P450 17α.