222312-73-4

Basic information

• Product Name: 2-benzyl-N,N,N',N'-tetramethylbutanediamide
• CAS NO: 222312-73-4
• Molecular Weight: 262.352
• Mol File: 222312-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyl-N,N,N',N'-tetramethylbutanediamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-N,N,N',N'-tetramethylbutanediamide(222312-73-4)
• EPA Substance Registry System: 2-benzyl-N,N,N',N'-tetramethylbutanediamide(222312-73-4)

Safety Data

• Hazardous Substances Data: 222312-73-4(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 7334-51-2 N,N,N',N'-tetramethylsuccinamide 
• 222312-71-2 2-(2-iodobenzyl)-N,N,N',N'-tetramethylbutanediamide 

Relevant articles and documents

Synthesis of succinimido[3,4-b]indane and 1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine-2,4-dione by sequential alkylation and intramolecular arylation of enolates derived from N,N,N'N'-tetramethylbutanediamides and N,N,N'N'-tetramethylpentanediamides

The tricyclic title compounds, 4 and 5, were synthesized by initial alkylation of the lithium monoenolates of N,N,N',N'-tetramethylbutanediamide (6) and N,N,N',N'-tetramethylpentanediamide (19) with 2-iodobenzyl chloride in liquid NH3 at -60°C to afford 2-(2-iodobenzyl)-N,N,N',N'-tetramethylbutanediamide (9) and 2-(2-iodobenzyl)-N,N,N',N'-tetramethylpentanediamide (20) in yields of 88 and 87%, respectively. Treatment of 9 with KNH2 in liquid NH3 resulted in formation and intramolecular arylation of the less-substituted α-enolate to produce trans-1,2-bis(N,N-dimethylcarboxamido)indane (10a) in 60% yield. Selective hydrolysis of 10a with aqueous Na2O2 gave trans-1-(N,N-dimethylcarboxamido)indane-2-carboxylic acid (17), which was then converted to bridged succinimide 4 by transformation to trans-1-(N,N-dimethylcarboxamido)indane-2-carboxamide (10c) followed by cyclization of this mixed primary/tertiary amide by means of NaH in refluxing THF. Treatment of 20 with KNH2 in liquid NH3 led to intramolecular arylation and accompanying ammonolysis to afford trans-1-(N,N-dimethylcarboxamido)-1,2,3,4-tetrahydronaphthalene-3-carboxamide (21b). Conversion of 21b to 5 was similarly effected by means of NaH. Experiments designed to test the mechanistic aspects of the intramolecular arylations provided evidence for competing aryne and SET pathways.