222313-83-9

Basic information

• Product Name: Ethanone, 1-(2-benzoxazolyl)-2,2,2-trifluoro- (9CI)
• Synonyms: Ethanone, 1-(2-benzoxazolyl)-2,2,2-trifluoro- (9CI)
• CAS NO: 222313-83-9
• Molecular Formula: C₉H₄F₃NO₂
• Molecular Weight: 215.1287696
• Product Categories: ACETYLHALIDE
• Mol File: 222313-83-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-benzoxazolyl)-2,2,2-trifluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-benzoxazolyl)-2,2,2-trifluoro- (9CI)(222313-83-9)
• EPA Substance Registry System: Ethanone, 1-(2-benzoxazolyl)-2,2,2-trifluoro- (9CI)(222313-83-9)

Safety Data

• Hazardous Substances Data: 222313-83-9(Hazardous Substances Data)

Upstream product

• 273-53-0 benzoxazole 
• 407-25-0 trifluoroacetic anhydride 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 930663-64-2 2-(1,3-benzoxazol-2-yl)-1,1,1-trifluoro-3-(4-nitrophenyl)propan-2-ol 

Relevant articles and documents

Cell death inhibitor and novel compound

Provided is a cell-death inhibitor including, as an active ingredient thereof, a compound represented by formula (1), and/or a compound represented by formula (2). The cell-death inhibitor exhibits high cell-death inhibition activity.

α-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines

Cytotoxic activity of newly synthesized trifluoromethyl ketones and related compounds was studied using two human oral tumor cell lines (HSG and HSC-2). Among them, α-trifluoromethylacyloins (1 and 2) were found to induce apoptotic cell death, as judged by the terminal deoxynucleotidyl transferase (TdT) dUTP nick end-labeling (TUNEL) method which detects DNA nick or fragments. Furthermore, the cytoplasm of 1 or 2 treated HSG cells was stained by M30 monoclonal antibody, which detects the product resulting from the cleavage of cytokeratin 18 by activated caspase.