222314-84-3Relevant academic research and scientific papers
A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide
Kalinin, Dmitrii V.,Kalinina, Svetlana A.,Dolzhenko, Anton V.
, p. 147 - 154 (2013/03/13)
The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines.
Synthesis and antimicrobial evaluation of novel pyrazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, triazolo[4,3-a]pyrimidine and pyrido[1,2-a]benzimidazole derivatives incorporated phenylsulfonyl moiety
Shaaban, Mohamed R.
scheme or table, p. 3005 - 3014 (2009/05/27)
Phenylsulfonylacetonitrile (1) reacts with dimethylformamide dimethyl acetal (DMF-DMA) to afford 3-(dimethylamino)-2-(phenylsulfonyl)acrylonitrile (2). Enaminonitrile 2 reacts with 5-aminopyrazole derivatives 3a-e, 5-amino-1,2,4-triazole (7) and 2-aminobenzimidazole (11) to afford new pyrazolo[1,5-a]pyrimidine, triazolo[4,3-a]pyrimidine and pyrimido[1,2-a]benzimidazole derivatives 4a-e, 9 and 12, respectively. Also, 3-(dimethylamino)-2-(phenylsulfonyl)acrylonitrile (2) reacts with 2-(1H-benzimidazol-2-yl)acetonitrile (13) to give the corresponding pyrido[l,2-a]benzimidazole derivative 15. Some of the newly synthesized compounds were tested in vitro for their antibacterial and antifungal activities, and showed promising results.
Polyfunctional fused heterocyclic compounds via indene-1,3-diones
Hassaneen, Hamdi M.,Abdallah, Tayseer A.,Abdelhadi, Hyam A.,Hassaneen, Huwaida M.E.,Pagni, Richard M.
, p. 491 - 497 (2007/10/03)
2-Dimethylaminomethylene- and 2-ethoxymethylene-1,3-indendione 1a,b react with 6-amino-2-thioxopyrimidin-4(3H)-one 2 in boiling acetic acid to give 2-thioxo-1,3-dihydroindeno[3,2-d]pyrimidino[4,5-b]pyridine-4,9-dione (4). The latter compound reacts with h
Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Isoxazole, Pyrimidine, Pyrazolo[1.5-a]pyrimidine, Pyrimido[1,2-a]benzimidazole and Pyrido[1,2a]benzimidazole Derivatives
Dawood, Kamal M.,Farag, Ahmad M.,Kandeel, Zaghloul E.
, p. 537 - 547 (2007/10/03)
A convenient synthesis of some new pyrazole, isoxazole, pyrimidine, pyrazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole and pyrido[1,2-a]benzimidazole derivatives is reported.
