55824-93-6Relevant academic research and scientific papers
A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation
Lim, Felicia Phei Lin,Luna, Giuseppe,Dolzhenko, Anton V.
, p. 5159 - 5163 (2014/12/10)
A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yiel
A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide
Kalinin, Dmitrii V.,Kalinina, Svetlana A.,Dolzhenko, Anton V.
, p. 147 - 154 (2013/03/13)
The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines.
2-ARYL-7-SUBSTITUTED PYRAZOLO[1,5a]1,3,5-TRIAZINES
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, (2014/02/13)
2-aryl-7-substituted pyrazolo[1,5a]1,3,5-triazine derivatives are disclosed which are useful as 3',5'-cyclic AMP phosphodiesterase inhibitors. These compounds are prepared by condensation of aryl- beta -ketonitrile derivatives with thiosemicarbazide which affords the corresponding 3-amino-2-thiocarbamoyl-5-aryl pyrazoles which, when heated with diethoxymethylacetate, give 2-aryl-7-mercapto pyrazolo [1,5a]1,3,5-triazines. The mercapto derivatives may then be methylated with methyl iodide to afford 2-aryl-7-methylthio-pyrazolo[1,5a]1,3,5,-triazines. Nucleophilic displacement of the methylthio moiety with various amines and sodium alkoxides yields the appropriately substituted 2-aryl-7-substituted pyrazolo[1,5a]1,3,5-triazines
