2224-80-8Relevant academic research and scientific papers
TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction
Hu, Jiaxing,Qin, Hua-Li,Xu, Wengang,Li, Junli,Zhang, Fanglin,Zheng, Hua
supporting information, p. 15780 - 15783 (2015/01/08)
A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.
Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVIII. 3-Alkoxy-1H-isoindole mit Substituenten am 5-Ring - Heterocycliche Imidsaeureester mit fixierter benzoider Struktur.
Kreher, Richard P.,Hennige, Hans,Konrad, Michael,Uhrig, Juergen,Clemens, Andrea
, p. 809 - 828 (2007/10/02)
3-Alkoxy-1H-isoindoles bearing substituents at the five-membered ring have been synthesized starting with substituted isoindoline-1-ones via regiospecific O-alkylation with trialkyl oxonium tetrafluoroborates or alkyl trifluoromethanesulfonates and subsequent NH-deprotonation.The dependence of spectroscopic properties on the substituents has been investigated.The heterocyclic imidates exist exclusively in the benzenoid 1H-structure; the tautomeric o-quinonoid 2H-form cannot be detected by spectroscopic means.
