26486-93-1

Basic information

• Product Name: 2,3-dihydro-3-hydroxy-1H-isoindol-1-one
• Synonyms: 2,3-dihydro-3-hydroxy-1H-isoindol-1-one;3-Hydroxy-2H-isoindole-1(3H)-one;3-Hydroxyisoindolin-1-one;3-HYDROXYPHTHALIMIDINE
• CAS NO: 26486-93-1
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.14668
• EINECS: 247-732-9
• Mol File: 26486-93-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 439.4°C at 760 mmHg
• Flash Point: 219.5°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 1.7E-08mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 2,3-dihydro-3-hydroxy-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-3-hydroxy-1H-isoindol-1-one(26486-93-1)
• EPA Substance Registry System: 2,3-dihydro-3-hydroxy-1H-isoindol-1-one(26486-93-1)

Safety Data

• Hazardous Substances Data: 26486-93-1(Hazardous Substances Data)

Usage

General Description

2,3-dihydro-3-hydroxy-1H-isoindol-1-one is a chemical compound with the molecular formula C8H7NO2. It is a cyclic compound containing a dihydroxyisoindole skeleton, which consists of a fused six-membered ring with two hydroxyl groups and a carbonyl group. 2,3-dihydro-3-hydroxy-1H-isoindol-1-one has been identified as a potential intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential applications in organic synthesis and material science. Additionally, it exhibits moderate to strong antimicrobial and antifungal activities, making it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C8H7NO2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-4,7,10H,(H,9,11)

Upstream product

• 67-56-1 methanol 
• 33081-78-6 sodium phthalimide 
• 110-83-8 cyclohexene 
• 136918-14-4 phthalimide 
• 123-91-1 1,4-dioxane 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 6940-49-4 3-Bromophthalide 
• 7664-41-7 ammonia 
• 71-43-2 benzene 
• 109-99-9 tetrahydrofuran 
• 856927-77-0 3-oxo-phthalan-1-sulfonic acid 
• 6295-21-2 3-chloro-1(3H)-isobenzofuranone 
• 1411995-95-3 S-(3-oxo-1,3-dihydro-2-benzofuran-1-yl)-N,N'-dimethylisothiuronium hydrobromide 

Downstream Products

• 26487-02-5 3-ethoxy-2,3-dihydro-1H-isoindol-1-one 
• 93679-80-2 3-p-toluidino-isoindolin-1-one 
• 109499-96-9 benzoic acid-[N'-(3-oxo-isoindolin-1-yl)-hydrazide] 
• 93679-79-9 3-phenethylamino-isoindolin-1-one 
• 6266-49-5 2-phenylphthalazin-1-one 
• 87-41-2 2-benzofuran-1(3H)-one 
• 88-97-1 phthalamic acid 
• 119-39-1 phthalazone 
• 51484-19-6 3-benzyl-3,4-dihydro-2H,10bH-[1,3,5]oxadidiazanediylidene[2,3-a]isoindol-6-one 

Relevant articles and documents

Synthesis of Isoindoles. Acid or Base Induced Cyclization of 2-Cyanobenzaldehyde with Alcohols

Various 3,3-dialkoxy-2,3-dihydro-1-hydroxy-1H-isoindoles (2) were obtained by treating 2-cyanobenzaldehyde (1) with alcohols in the presence of an acid catalyst such as silica gel.In the reaction using a base catalyst such as triethylamine and 1,8-diazabi

FUSED IMIDAZOLE AND PYRAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5- α]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human a

A concise synthesis of 3-(1-alkenyl)isoindolin-1-ones and 5-(1-alkenyl)pyrrol-2-ones by the intermolecular coupling reactions of N-acyliminium ions with unactivated olefins

A concise synthesis of 3-(1-alkenyl)isoindolin-1-ones and 5-(1-alkenyl)pyrrol-2-ones has been achieved by the coupling reactions of N-acyliminium ions produced from 3-hydroxyisoindol-1-ones or 5-hydroxy-1-pyrrol-2-ones with unactivated olefins in the presence of BF 3·OEt2 at room temperature. For most of the olefins,the reactions afforded the Csp3-Csp2 cross-coupling products,but for the α-methylstyrene and 1-hexene,the Csp3-Csp3 cross-coupling products were obtained.