22249-33-8

Upstream product

• 74-88-4 methyl iodide 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 74851-58-4 5-tert-butyl-2-oxocyclohexanecarboxylic acid methyl ester 

Downstream Products

• 87373-03-3 trans-5-tert-butyl-1-methyl-2-oxocyclohexanecarboxylic acid 
• 87373-10-2 (1S,2S,4R)-4-tert-Butyl-2-hydroxymethyl-2-methyl-cyclohexanol 
• 87373-09-9 (1SR,2RS,4SR)-4-(tert-butyl)-2-(hydroxymethyl)-2-methylcyclohexan-1-ol 

Relevant academic research and scientific papers

Synthesis of fused bicyclic rings by tandem radical ring expansion/cyclization: Evaluating competing intramolecular reactions

One- and three-carbon 'Dowd-Beckwith' ring expansions of cyclopentanones and cyclohexanones are generally successful, but tandem expansion/cyclization reactions can be compromised by competing processes. An evaluation of the competition between ring expansion, 1,5-hydrogen transfer, and 6-exo cyclization provides information on how to design successful tandem expansion cyclization sequences.

Kinetics of Decarboxylation of the Two Epimers of 5-tert-Butyl-1-methyl-2-oxocyclohexanecarboxylic Acid: Lack of Stereoelectronic Control in β-Keto Acid Decarboxylation

Rates of decarboxylation of the two epimers of 5-tert-butyl-1-methyl-2-oxocyclohexanecarboxylic acid have been measured under both acidic and basic conditions at 25 deg C.The decomposition of isomer 1e (methyl and tert-butyl trans) is more rapid than that