2225-18-5Relevant articles and documents
Oxidative chlorination, desulphonation, or decarboxylation to synthesize pharmaceutical intermediates: 2,6-Dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol
Mukhopadhyay,Chandalia
, p. 10 - 16 (2013/09/08)
An alternative manufacturing process scheme was developed for 2,6-dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol, involving oxidative chlorination after protection of the starting material in the para position followed by deprotection involving desulphonation or decarboxylation. Oxidative chlorination of 4-methylbenzenesulphonic acid, 4-methylbenzoic acid, 4-aminobenzoic acid, and 4-hydroxybenzoic acid by using HCl-H2O2, and their subsequent desulphonation or decarboxylation, gave a 60-75% yield of the desired product.
