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(1R,2S)-2-(ISOPROPYLAMINO)-1,2-DIPHENYLETHANOL is a chiral secondary alcohol belonging to the class of organic compounds. It features a unique stereochemistry, designated as (1R,2S), and is characterized by the presence of a secondary alcohol group, an isopropylamine group, and two phenyl groups. (1R,2S)-2-(ISOPROPYLAMINO)-1,2-DIPHENYLETHANOL is widely recognized for its utility as a chiral building block in organic synthesis and as a key intermediate in the development of pharmaceuticals and agrochemicals. Its chiral nature is particularly valuable, as it serves as an important starting material for synthesizing enantiomerically pure compounds.

222555-57-9

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222555-57-9 Usage

Uses

Used in Pharmaceutical Industry:
(1R,2S)-2-(ISOPROPYLAMINO)-1,2-DIPHENYLETHANOL is used as a chiral building block for the synthesis of various pharmaceuticals. Its unique stereochemistry and functional groups enable the creation of enantiomerically pure compounds, which are essential for ensuring the desired biological activity and minimizing potential side effects in drug development.
Used in Agrochemical Industry:
In the agrochemical sector, (1R,2S)-2-(ISOPROPYLAMINO)-1,2-DIPHENYLETHANOL is utilized as a key intermediate in the preparation of enantiomerically pure active ingredients for pesticides and other agrochemical products. Its chiral properties allow for the development of more effective and targeted agrochemicals with reduced environmental impact.
Used in Organic Synthesis:
(1R,2S)-2-(ISOPROPYLAMINO)-1,2-DIPHENYLETHANOL is employed as a versatile chiral building block in organic synthesis. Its presence in various chemical reactions can lead to the formation of a wide range of enantiomerically pure compounds, which are crucial for various applications, including the development of new drugs, agrochemicals, and other specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 222555-57-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,5,5 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 222555-57:
(8*2)+(7*2)+(6*2)+(5*5)+(4*5)+(3*5)+(2*5)+(1*7)=119
119 % 10 = 9
So 222555-57-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO/c1-13(2)18-16(14-9-5-3-6-10-14)17(19)15-11-7-4-8-12-15/h3-13,16-19H,1-2H3/t16-,17+/m0/s1

222555-57-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (1R,2S)-2-(isopropylamino)-1,2-diphenylethan-1-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:222555-57-9 SDS

222555-57-9Relevant academic research and scientific papers

Indium-mediated Barbier-type allylation of aldehydes as a convenient method for the highly enantioselective synthesis of homoallylic alcohols

Hirayama, Lacie C.,Gamsey, Soya,Knueppel, Daniel,Steiner, Derek,Delatorre, Kelly,Singaram, Bakthan

, p. 2315 - 2318 (2007/10/03)

We report a general method for the indium-mediated Barbier-type enantioselective allylation of both aromatic and aliphatic aldehydes using commercially available (1S,2R)-(+)-2-amino-1,2-diphenylethanol as a chiral auxiliary. Using only two equivalents of allyl bromide, excellent yields and very good to excellent enantioselectivities are obtained. To our knowledge, the enantioselectivities reported herein are the highest obtained for indium-promoted allylations of carbonyl compounds.

Easily accessible chiral amino-phosphinite ligands for highly enantioselective palladium-mediated allylic alkylation

Chen, Guoshu,Li, Xin,Zhang, Haile,Gong, Liuzhu,Mi, Aiqiao,Cui, Xin,Jiang, Yaozhong,Choi, Michael C.K.,Chan, Albert S.C.

, p. 809 - 813 (2007/10/03)

Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with the dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of easily prepared new chiral amino-phosphinite ligands such as 3b and 3c to

New 1-amino-1,2-diphenylethanols as ligands for the enantioselective addition of alkyllithiums to benzaldehyde

Schoen, Michael,Naef, Reto

, p. 169 - 176 (2007/10/03)

In the presence of equimolar amounts of lithium alkoxides derived from N-substituted 2-amino-1,2-diphenylethanols, alkyllithium reagents add to benzaldehyde to furnish optically active secondary alcohols with enantiomeric excesses of up to 86%. The best results were obtained using the N-isopropyl- N-methyl substituted amino-alcohol.

Studies on reaction conditions and new entry to chiral ligands in the chiral lithium amide-mediated enantioselective aldol reaction

Ando,Tatematsu,Shioiri

, p. 1967 - 1971 (2007/10/02)

Reaction conditions for the enantioselective aldol reaction of 2,2-dimethyl-3-pentanone (3) and benzaldehyde using the chiral lithium amide 1b as a chiral auxiliary were thoroughly investigated. All three procedures, that is, (1) the combined use of lithi

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