22258-71-5

Upstream product

• 21344-50-3 3-(β-hydroxyethyl)benzothiazolin-2-one 
• 16954-69-1 2-methylaminobenzthiazole 
• 107-07-3 2-chloro-ethanol 
• 28291-69-2 2-ethylaminobenzothiazole 
• 18392-47-7 2-β-hydroxyethylaminobenzothiazole 
• 136-95-8 2-amino-benzthiazole 
• 934-34-9 2(3H)-Benzothiazolone 
• 107-04-0 1-Bromo-2-chloroethane 
• 624-70-4 1-chloro-2-iodoethane 
• 934-34-9 2-hydroxybenzothiazole 

Relevant academic research and scientific papers

On interaction of 2-amino-benzothiazoles with halohydrins

Interaction of 2-aminobenzothiazoles with ethylene chlorohydrin on boiling leads mainly to formation of the corresponding 3-(β-chloroethyl)benzothiazolin-2-ones. Reducing the reaction temperature increases the fraction of 2-imino-(3-β-hydroxyethyl)benzothiazolines. In both instances formation of bis[3-(β-hydroxyethyl)benzothiazol-2-ylidene]ammonium chlorides is observed. The reaction of 2-aminobenzothiazole with propylene bromohydrin gives only the corresponding amino alcohols. The anomalous products from the reaction of β-chloroethyl derivatives of benzothiazolinones result from a dominating side reaction of the starting 2-aminobenzothiazoles with the ethylene chlorohydrin thermolysis products that are formed on boiling. 1999 KluwerAcademic/Plenum Publishers.

Reactions of 2-aminobenzothiazoles with ethylene chlorohydrin, molecular and crystal structure of bis[(3-β-hydroxyethyl)benzothiazolyl-2-endene]ammonium chloride

Hydroxyethylation of 2-aminobenzothiazoles by ethylene chlorohydrin unexpectedly led to preferential formation of 3-β-chloroethylbenzothiazolin-2-one. In the case of unsubstituted 2-aminobenzothiazole, we also isolated the target 2-imino-3-β-hydroxyethylbenzothiazoline and bis[(3-β-hydroxyethyl)benzothiazolyl-2-indene]ammonium chloride. As a result of reaction of 2-aminobenzothiazole with 3-β-chloroethylbenzothiazolin-2-one, we obtained 2-(benzothiazolyl-2-imino)-3-[β-(2-oxobenzothiazolin-3-yl)ethyl] benzothiazoline. The structure of the synthesized compounds was established based on x-ray diffraction, PMR, IR, UV, and mass spectra. 1997 Plenum Publishing Corporation.

Benzimidazolidinone derivatives as muscarinic agents

Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships

Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.