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(1R,2S)-2-(N,N-dimethylamino)-1-phenyl-1-(thioacetoxy)propane is a chiral organic compound with a molecular formula of C13H21NOS2. It is a derivative of 1-phenyl-1-(thioacetoxy)propane, featuring a dimethylamino group at the 2-position and a thioacetoxy group at the 1-position. The compound exhibits a specific stereochemistry, with the R configuration at the 1st carbon and the S configuration at the 2nd carbon. This chiral compound has potential applications in the synthesis of pharmaceuticals and agrochemicals, as well as in the study of stereoselective reactions. Its unique structure and properties make it an interesting target for research in the field of organic chemistry.

2226-23-5

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2226-23-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2226-23-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,2 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2226-23:
(6*2)+(5*2)+(4*2)+(3*6)+(2*2)+(1*3)=55
55 % 10 = 5
So 2226-23-5 is a valid CAS Registry Number.

2226-23-5Downstream Products

2226-23-5Relevant academic research and scientific papers

Nucleophilic substitutions using O-alkyl-N,N'-dialkylisoureas. Applications to ephedrines

Poelert, Martin A.,Hulshof, L. A.,Kellogg, Richard M.

, p. 365 - 368 (2007/10/02)

Dialkylcarbodiimides in the presence of a Cu(I) catalyst react cleanly with the hydroxyl group of N-methylated (1R,2S)-ephedrine and (1S,2S)-pseudoephedrine.These adducts react with nucleophiles like alkyl and aryl thiols as well as thioic acids and phthalimide to form the substitution products with overall retention of configuration.It is postulated that intramolecular paricipation of the amino group via an SN2 reaction leads to aziridium salts, which are subsequently opened by the nucleophiles via a second SN2 reaction.This synthetic approach is also useful for the inversion of simple secondary alcohols; on treatment with dicyclohexylcarbodiimide followed by benzothioic acid and treatment with LiAlH4, menthol was converted in good yield to neomenthane thiol.

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