22266-04-2Relevant academic research and scientific papers
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Gold, Ben,Smith, Robert,Nguyen, Quyen,Roberts, Julia,Ling, Yan,Lopez Quezada, Landys,Somersan, Selin,Warrier, Thulasi,Little, David,Pingle, Maneesh,Zhang, David,Ballinger, Elaine,Zimmerman, Matthew,Dartois, Véronique,Hanson, Paul,Mitscher, Lester A.,Porubsky, Patrick,Rogers, Steven,Schoenen, Frank J.,Nathan, Carl,Aubé, Jeffrey
, p. 6027 - 6044 (2016/07/26)
We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host, and whose bactericidal activity is not dependent upon or enhanced by clavulanate, a β-lactamase inhibitor. The two classes of cephalosporins bear an ester or alternatively an oxadiazole isostere at C-2 of the cephalosporin ring system, a position that is almost exclusively a carboxylic acid in clinically used agents in the class. Representatives of the series kill M. tuberculosis within macrophages without toxicity to the macrophages or other mammalian cells.
β-Lactam Antibiotics. Part 2. New Methods of Cyclising Hydrazinothioazetidinones to Cephem Ring Systems
Foglio, Maurizio,Francheschi, Giovanni,Masi, Paolo,Suarato, Antonino
, p. 233 - 236 (2007/10/02)
Base-induced and oxidative cyclisation of hydrazinothioazetidinones as novel routes to cephem ring systems are described together with the proposed mechanisms.General procedures for these cyclisations are reported.
