129681-71-6

Basic information

• Product Name: 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine
• CAS NO: 129681-71-6
• Molecular Weight: 787.988
• Mol File: 129681-71-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine(129681-71-6)
• EPA Substance Registry System: 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N₆-benzoyl adenosine(129681-71-6)

Safety Data

• Hazardous Substances Data: 129681-71-6(Hazardous Substances Data)

Upstream product

• 129666-75-7 6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 4546-55-8 N-benzoyladenosine 
• 1348775-39-2 adenosine 
• 98-88-4 benzoyl chloride 
• 58-61-7 adenosine 
• 401812-98-4 3’,5’-O-bis(t-butylsilyl)-2’-O-(t-butyldimethylsilyl)-N6-benzoyladenosine 
• 212375-93-4 3’,5’-O-bis(t-butylsilyl)-2’-O-(t-butyldimethylsilyl)adenosine 
• 97219-09-5 3',5'-O-(Di-tert-butylsilanediyl)adenosine 
• 69504-07-0 N⁶-benzoyl-2'-O-(tert-butyldimethylsilyl)adenosine 

Downstream Products

• 104992-55-4 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 1005482-73-4 (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl trifluoromethane-sulfonate 
• 131316-88-6 Succinic acid mono-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl] ester 
• 136044-34-3 N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diethylphosphoramidite) 
• 160056-44-0 C₁₀H₁₃N₅O₄SiC₆H₁₄PO₃HC(C₆H₅)3C₂H₃O₂C₇H₄C₆H₄ 
• 81279-42-7 5'-dimethoxytrityl 2'-tert-butyldimethyl silyl N-benzoyladenosine 3'-p-chlorophenyl β-cyanoethyl phosphotriester 
• 127553-42-8 5'-O-DMTr-2'-O-TBDMS-N-Bz-adenosine-3'-O-(2-chlorophenyl)phosphate triethylammonium salt 
• 75074-02-1 N⁶-Benzoyl-2'-O-(tert-butyldimethylsilyl)adenosin-3'-(o-chlorphenyl)(β-cyanethyl)phosphat 
• 1374755-65-3 C₅₇H₆₅N₆O₈PS₂Si 
• 1222078-42-3 C₅₂H₅₄N₈O₈Si 
• 118380-97-5 C₄₇H₅₈N₇O₁₃PSi*H₃N 
• 100638-43-5 Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester 2-cyano-ethyl ester 

Relevant articles and documents

CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Synthesis of 2'-O-substituted ribonucleosides.

An efficient synthesis of 2'-O-substituted ribonucleosides, including 2'-O-TBDMS and 2'-O-TOM protected as well as 2'-O-Me and 2'-O-allyl derivatives is presented. Di-t-butylsilylene group was employed for simultaneous protection of 3'- and 5'- hydroxyl functions of nucleoside on the first step. Subsequent silylation or alkylation of free 2'-OH followed by introduction of suitable protection on the base moiety and removal of cyclic silyl protection gave target compounds in a high yield.