222727-43-7

Usage

Uses

Used in Medical Imaging:
Cyclobutanecarboxylic acid, 1-amino-3-fluoro-, trans(9CI) is used as a precursor for labelled anti-[F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid, which serves as a positron emission tomography (PET) tracer. The application reason for this use is to aid in the delineation and detection of tumors within the body. The PET tracer allows for the visualization of cancerous cells, enabling more accurate diagnosis and treatment planning for patients with various types of cancer.

Upstream product

• 191110-49-3 2-(benzyloxy)-5,7-diazaspiro[3.4]octane-6,8-dione 
• 222727-35-7 1-t-butyl carbamate-3-hydroxy-1-cyclobutane-1-carboxylic acid methyl ester 
• 222727-29-9 1-amino-3-benzyloxycyclobutane-1-carboxylic acid 
• 222727-41-5 1-t-butyl carbamate-3-fluoro-1-cyclobutane-1-carboxylic acid methyl ester 
• 222727-33-5 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid methyl ester 
• 222727-31-3 1-t-butyl carbamate-3-benzyloxy-1-cyclobutane-1-carboxylic acid 

Relevant academic research and scientific papers

Stereoselective synthesis and biological evaluation of syn-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid as a potential positron emission tomography brain tumor imaging agent

Amino acid syn-1-amino-3-fluoro-cyclobutyl-1-carboxylic acid (syn-FACBC) 12, the isomer of anti-FACBC, has been selectively synthesized and [18F] radiofluorinated in 52% decay-corrected yield using no-carrier-added [18F]fluoride. The key step in the synthesis of the desired isomer involved stereoselective reduction using lithium alkylborohydride/zinc chloride, which improved the ratio of anti-alcohol to syn-alcohol from 17:83 to 97:3. syn-FACBC 12 entered rat 9L gliosarcoma cells primarily via L-type amino acid transport in vitro with high uptake of 16% injected dose per 5 × 105 cells. Biodistribution studies in rats with 9L gliosarcoma brain tumors demonstrated high tumor to brain ratio of 12:1 at 30 min post injection. In this model, amino acid syn-[18F]FACBC 12 is a promising metabolically based radiotracer for positron emission tomography brain tumor imaging.

NOVEL ORGANIC COMPOUND AND METHOD FOR PRODUCING RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND USING THE SAME

It is intended to provide a precursor compound to be labeled for selectively producing syn-1-amino-3-cyclobutanecarboxylic acid substituted with a radioactive halogen and a method for producing syn-1-amino-3-cyclobutanecarboxylic acid substituted with a r

Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC): A pet tracer for tumor delineation

Fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), a new tumor-avid amino acid, was synthesized for positron emission tomography. [18F]FACBC was prepared with high specific activity by nucleophilic displacement with an o