22273-65-0

Basic information

• Product Name: 4-anilinofuran-2(5H)-one
• Synonyms: 4-anilinofuran-2(5H)-one;4-(Phenylamino)-2(5H)-furanone;4-Anilino-2,5-dihydrofuran-2-one;Einecs 244-884-8
• CAS NO: 22273-65-0
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• EINECS: 244-884-8
• Mol File: 22273-65-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 358.6°Cat760mmHg
• Flash Point: 170.7°C
• Appearance: /
• Density: 1.322g/cm³
• Vapor Pressure: 2.52E-05mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 4-anilinofuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-anilinofuran-2(5H)-one(22273-65-0)
• EPA Substance Registry System: 4-anilinofuran-2(5H)-one(22273-65-0)

Safety Data

• Hazardous Substances Data: 22273-65-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9NO2/c12-10-6-9(7-13-10)11-8-4-2-1-3-5-8/h1-6,11H,7H2

Upstream product

• 90766-46-4 4-anilino-3-bromo-5H-furan-2-one 
• 62-53-3 aniline 
• 4971-56-6 tetrahydrofuran-2,4-dione 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 541-57-1 4-hydroxy-2(5H)-furanone 
• 4916-29-4 dimethyl 2-(phenyl-amino)-2-butendioate 

Downstream Products

• 728885-50-5 2-amino-2',5-dioxo-1-phenyl-5,7-dihydro-1H-spiro[furo[3,4-b]pyridine-4,3' indoline]-3-carbonitrile 
• 1579950-57-4 ethyl 3-oxo-1-(2-oxo-4-(phenylamino)-2,5-dihydrofuran-3-yl)isoindoline-1-carboxylate 
• 1482447-88-0 C₂₆H₂₁BrN₂O₄ 
• 1482447-63-1 C₂₆H₂₁N₃O₆ 
• 1482447-50-6 C₂₆H₂₂N₂O₄ 
• 1414774-58-5 5-hydroxy-5-(2-oxo-4-(phenylamino)-2,5-dihydrofuran-3-yl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1195771-08-4 10-(4-bromophenyl)-4-phenyl-4,10-dihydro-3H-2-oxa-4-aza-cyclopenta[b]fluorene-1,9-dione 

Relevant articles and documents

Highly active magnetically separable CuFe2O4 nanocatalyst: An efficient catalyst for the green synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H) dione derivatives

A facile and efficient procedure has been reported for the synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-diones by the condensation reaction of benzaldehydes, 1,3-cyclohexanediones and anilinolactones in the presence of CuFe2O4 as a reusable nanocatalyst with high catalytic activity in water. The notable advantages of this method are excellent isolated yields, short reaction times, simple workup procedure and little environmental impact. Graphical Abstract: [Figure not available: see fulltext.].

Synthesis of 3-bromotetronamides via amination of 3,4-dibromofuran-2(5H)- one

This work describes the direct synthesis of 3-bromotetronamides in good yields through the reaction of 3,4-dibromofuran-2(5H)-one, obtained from furfural, with primary and secondary amines. Aromatic amines were more tolerated than aliphatic and heteroaromatic ones. The X-ray structures of five derivatives are described.

A facile synthesis of the 4-aza-analogs of 1-arylnaphthalene lignans chinensin, justicidin B, and Taiwanin C

Reaction of anilines 1a-d with retronic acid (2) or 1,3- cyclopentanedione (3) produced anilinolactones 4a-d and anilinocyclopentenone 5a, respectively, which were then condensed with benzaldehydes to yield 4- aza-1-arylnaphthalene lignan analogs 6-19.