222737-09-9

Basic information

• Product Name: Acetyl-(4-phosphono)-L-tyrosyl-L-leucine N-[1(S)-(4-isopropylphenyl)ethyl]amide
• CAS NO: 222737-09-9
• Molecular Formula: C₂₈H₄₀N₃O₇P
• Molecular Weight: 561.6207
• Mol File: 222737-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetyl-(4-phosphono)-L-tyrosyl-L-leucine N-[1(S)-(4-isopropylphenyl)ethyl]amide(CAS DataBase Reference)
• NIST Chemistry Reference: Acetyl-(4-phosphono)-L-tyrosyl-L-leucine N-[1(S)-(4-isopropylphenyl)ethyl]amide(222737-09-9)
• EPA Substance Registry System: Acetyl-(4-phosphono)-L-tyrosyl-L-leucine N-[1(S)-(4-isopropylphenyl)ethyl]amide(222737-09-9)

Safety Data

• Hazardous Substances Data: 222737-09-9(Hazardous Substances Data)

Upstream product

• 52629-44-4 4-(1-methylethyl)-benzeneacetyl chloride 
• 537-55-3 N-acetyl-L-tyrosine 
• 95976-43-5 (S)-2-(4'-isopropylphenyl) propionic acid 
• 222737-12-4 (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-4-methyl-pentanoic acid allyl ester 
• 222737-13-5 (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-4-methyl-pentanoic acid 
• 151608-48-9 N-acetyl-O-[bis(benzyloxy)phosphoryl]-L-tyrosine 
• 222737-10-2 (S)-4-Isopropyl-3-[(S)-2-(4-isopropyl-phenyl)-propionyl]-oxazolidin-2-one 
• 222737-11-3 [(S)-1-(4-Isopropyl-phenyl)-ethyl]-carbamic acid benzyl ester 
• 68285-22-3 (S)-1-(4-isopropylphenyl)ethylamine 

Relevant articles and documents

Phosphotyrosine-containing dipeptides as high-affinity ligands for the p56(lck) SH2 domain

Src homology-2 (SH2) domains are noncatalytic motifs containing approximately 100 amino acid residues that are involved in intracellular signal transduction. The phosphotyrosine-containing tetrapeptide Ac-pYEEI binds to the SH2 domain of p56(lck) (Lck) with an affinity of 0.1 μM. Starting from Ac-pYEEI, we have designed potent antagonists of the Lck SH2 domain which are reduced in peptidic character and in which the three carboxyl groups have been eliminated. The two C-terminal amino acids (EI) have been replaced by benzylamine derivatives and the pY + 1 glutamic acid has been substituted with leucine. The best C-terminal fragment identified, (S)-1-(4-isopropylphenyl)ethylamine, binds to the Lck SH2 domain better than the C-terminal dipeptide EI. Molecular modeling suggests that the substituents at the 4-position of the phenyl ring occupy the pY + 3 lipophilic pocket in the SH2 domain originally occupied by the isoleucine side chain. This new series of phosphotyrosine-containing dipeptides binds to the Lck SH2 domain with potencies comparable to that of tetrapeptide 1.