22280-97-3

Usage

InChI:InChI=1/C11H12O4/c1-3-6-15-9-5-4-8(11(12)13)7-10(9)14-2/h3-5,7H,1,6H2,2H3,(H,12,13)

Upstream product

• 119870-95-0 ethyl 4-allyloxy-3-methoxybenzoate 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 106-95-6 allyl bromide 

Downstream Products

• 22281-12-5 5-methoxy-2-nitro-4-(2-propenoxy)benzoic acid 
• 86534-11-4 3-methoxy-4-(2-propenyloxy) benzenemethanol 

Relevant academic research and scientific papers

Novel domino synthesis of 2-(2,3.4-substituted phenyl) quinazolin-4-amine

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with isopropyl amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives.

Chemoselective hydrolysis of tert-butyl esters in acetonitrile using molecular iodine as a mild and efficient catalyst

A simple, mild and efficient method for the hydrolysis of tert-butyl esters using molecular iodine as a catalyst is described. Acid labile protecting groups, such as N-Boc, OBn, OAc and double bonds, are compatible under the reaction conditions.

Montmorillonite clay: A novel reagent for the chemoselective hydrolysis of t-butyl esters

A mild and highly selective hydrolysis of t-butyl esters has been achieved in high yields using montmorillonite KSF in refluxing acetonitrile. The method is compatible with a variety of protecting and functional groups such as BOC, Cbz, propargyl, allyl, benzyl, t-butyl ethers, allyl, methyl and benzyl esters present in the molecule.

Design and synthesis of a novel epoxide-containing pyrrolo[2,1-c[]1,4]benzodiazepine (PBD) via a new cyclization procedure

The synthesis of a potential DNA-crosslinking pyrrolo[2,1-c]-[1,4]benzodiazepine (PBD) substituted at the C8-position with a 2,3-epoxypropaneoxy moiety using a new cyclization procedure is described.