222854-34-4

Basic information

• Product Name: 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate
• Synonyms: 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate
• CAS NO: 222854-34-4
• Molecular Formula: C23H26N2O4
• Molecular Weight: 394.46354
• Mol File: 222854-34-4.mol

Chemical Properties

• Melting Point: 28-32 °C
• Boiling Point: 506.7±43.0 °C(Predicted)
• Appearance: /
• Density: 1.232±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.93±0.20(Predicted)
• CAS DataBase Reference: 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate(222854-34-4)
• EPA Substance Registry System: 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate(222854-34-4)

Safety Data

• Hazardous Substances Data: 222854-34-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate is used as a potential pharmaceutical agent for its anti-inflammatory, analgesic, and antipyretic properties. 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate's structure, which includes a fluorenylmethyl group and a tert-butyl substituent, may provide additional benefits in drug development, such as improved stability or bioavailability.
Used in Drug Development:
In the field of drug development, 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate may be utilized as a starting material or a structural component in the design of new drugs. The unique properties of the fluorenyl group and the tert-butyl substituent could be exploited to enhance the compound's pharmacological profile or to improve its interaction with biological targets.
Further research and testing are necessary to fully understand the potential uses and properties of 1-((9H-Fluoren-9-yl)Methyl) 2-tert-butyl pyrazolidine-1,2-dicarboxylate, as well as to explore its potential applications in other industries beyond pharmaceuticals and drug development.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 57699-91-9 tert-butyl pyrazolidine-1-carboxylate 

Downstream Products

• 1093755-81-7 fluoren-9-yl-methyl pyrazolidine-1-carboxylate hydrochloride 

Relevant articles and documents

Microwave-assisted solid-phase aza-peptide synthesis: Aza scan of a PKB/Akt inhibitor using aza-arginine and aza-proline precursors

Aza-peptides are peptidomimetics in which one or more of the α-carbons, bearing the side-chain residues, has been replaced by a nitrogen. These peptidomimetics have been shown to be promising for the generation of drug leads and for structure-activity rel

Azapeptides as CD36 binding compounds

An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa′)b-B??I.

Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a

The synthetic hexapeptide growth hormone releasing peptide-6 (GHRP-6) exhibits dual affinity for the growth hormone secretagogue receptor 1a (GHS-R1a) and the cluster of differentiation 36 (CD36) receptor. Azapeptide GHRP-6 analogues have been synthesized, exhibiting micromolar affinity to the CD36 receptor with reduced affinity toward the GHS-R1a. A combinatorial split-and-mix approach furnished aza-GHRP-6 leads, which were further examined by alanine scanning. Incorporation of an aza-amino acid residue respectively at the d-Trp2, Ala3, or Trp4 position gave aza-GHRP-6 analogues with reduced affinity toward the GHS-R1a by at least a factor of 100 and in certain cases retained affinity for the CD36 receptor. In the latter cases, the d-Trp2 residue proved important for CD36 receptor affinity; however, His1 could be replaced by Ala1 without considerable loss of binding. In a microvascular sprouting assay using a choroid explant, [azaTyr4]-GHRP-6 (15), [Ala1, azaPhe 2]-GHRP-6 (16), and [azaLeu3, Ala6]-GHRP-6 (33) all exhibited antiangiogenic activity.

Azapeptide acids as cell adhesion inhibitors

Azapeptide acids of Formula I are antagonists of VLA-4 and/or alpha 4 beta 7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical composition