22287-70-3

Upstream product

• 108-46-3 recorcinol 
• 67091-10-5 1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone 
• 106-96-7 propargyl bromide 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Relevant academic research and scientific papers

Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones

A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.

Synthesis and Antimicrobial Activity of Bis-1,2,3-triazole Based Chalcones

A series of bis-1,2,3-triazole based chalcones has been synthesized in high yields. The newly synthesized compounds are characterized by IR, NMR and mass spectroscopy. The combination of the pharmacologically active moieties in a single scaffold results i

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Furthermore, some drugs are associated with the emergence of drug resistance. Thus

Design, Synthesis, and Biological Activity of New Bis-1,2,3-triazole Derivatives Bearing Thiophene-Chalcone Moiety

A series of novel 1,4-substituted bis-aralkyl and aryl 1,2,3-triazoles bearing thiophene chalcones are synthesized via the Claisen condensation of bis propargyl acetophenone intermediate with thiophene-2-carboxaldehyde followed by the Huisgen cycloaddition of the accumulated bis propargyl chalcone intermediate with various aryl and aralkyl azides. Structures of the synthesized compounds are characterized by IR, NMR and mass spectroscopy. The products are tested for antimicrobial and antioxidant activities, and some of those exhibit antibacterial and antifungal activity. The moderate to poor DPPH free radical scavenging activity is determined for some products.

Benzofurans from acetophenones by Claisen rearrangement

The condensation of acetophenones with propargylbromide in acetone-potassium carbonate medium yielded propargyloxyacetophenones which on thermal cyclisation leads to Claisen rearrangement to give 2-methylbenzofuran and 2,4-dimethyl benzodifurans.