22287-70-3Relevant articles and documents
Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
Sunitha,Kumar, A. Kishore,Mahesh,Shankaraiah,Jalapathi,Lincoln, Ch. Abraham
, p. 1904 - 1911 (2018)
A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized compounds are characterized by IR, NMR and Mass spectroscopy. The target compounds 7a–7j are assessed for their antimicrobial activity and these demonstrate high to excellent activity against tested bacterial and fungal strains. The products 7f, 7h, 7j, and 7i demonstrate potent antimicrobial activity at concentrations 75 and 100 μg/mL.
Identification of chalcone-based antileishmanial agents targeting trypanothione reductase
Ortalli, Margherita,Ilari, Andrea,Colotti, Gianni,De Ionna, Ilenia,Battista, Theo,Bisi, Alessandra,Gobbi, Silvia,Rampa, Angela,Di Martino, Rita M.C.,Gentilomi, Giovanna A.,Varani, Stefania,Belluti, Federica
, p. 527 - 541 (2018)
All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Furthermore, some drugs are associated with the emergence of drug resistance. Thus
Benzofurans from acetophenones by Claisen rearrangement
Sanath Kumar,David Krupadanam,Akshaya Kumar,Gourishankar
experimental part, p. 887 - 889 (2011/04/25)
The condensation of acetophenones with propargylbromide in acetone-potassium carbonate medium yielded propargyloxyacetophenones which on thermal cyclisation leads to Claisen rearrangement to give 2-methylbenzofuran and 2,4-dimethyl benzodifurans.
