67091-10-5Relevant academic research and scientific papers
Synthesis and Cytotoxicity of Chalcone Based 1,2,3-Triazole Derivatives
Jalapathi, P.,Kumar, A. Kishore,Raghavender, M.,Sunitha, V.,Vishnu, T.
, p. 697 - 702 (2020)
Abstract: Synthesis of a novel series of chalcone based 1,2,3-triazole derivatives and their anti-cancer studies are presented. Majority of the target compounds exhibit moderate to excellent activity against A-549 cells. Among the compounds screened 7c an
Tryptamine–Triazole Hybrid Compounds for Selective Butyrylcholinesterase Inhibition
Son, Minky,Lee, Haneul,Jeon, Cheolmin,Kang, Yujung,Park, Chanin,Lee, Keun Woo,Park, Jeong Ho
, p. 544 - 553 (2019)
Tryptamine–triazole hybrid compounds (11–18) were synthesized via click reaction between tryptamine azide and propargylated natural compounds. Their cholinesterase inhibitory activity was evaluated. Among the eight compounds, compound 11 showed the most p
Synthesis and Antibacterial Activity of Some {6-[(1H-1,2,3-Triazol-4-yl)methoxy]-3-methylbenzofuran-2-yl}(4-bromophenyl)methanone Derivatives
Kishore Kumar,Sunitha,Shankaraiah,Siddhartha,Jalapathi
, p. 789 - 796 (2018)
A series of novel benzofuran?1,2,3-triazole hybrid heterocyclic molecules were synthesized using a click chemistry approach. The structure of the synthesized compounds was assessed by IR and NMR spectroscopy and mass spectrometry. The products showed moderate to high activity against gram-positive and gram-negative bacteria.
A tryptamine-paeonol hybridization compound inhibits LPS-mediated inflammation in BV2 cells
Jung, Eun-Hye,Hwang, Ji-Sun,Kwon, Mi-Youn,Kim, Kyung-Hong,Cho, Hyeongjin,Lyoo, In Kyoon,Shin, Sujeong,Park, Jeong-Ho,Han, Inn-Oc
, p. 35 - 43 (2016)
In the present study, we synthesized and evaluated the anti-inflammatory effects of three tryptamine (Trm) hybrid compounds, HBU-375, HBU-376 and HBU-379. The Click reaction between the azido-Trm and 2- or 4-propazylated paeonol moiety resulted in HBU-376
Synthesis and antimicrobial activity of some novel benzofuran based 1,2,3-triazoles
Sunitha,Kishore Kumar,Shankar,Anil Kumar,Krishna,Lincoln, Ch. A.,Pochampalli
, p. 322 - 330 (2017)
In the present study, a series of novel {6-[(1H-1,2,3-triazol-4-yl)methoxy]-3-methylbenzofuran-2-yl}(phenyl)methanones (7a–7o) have been synthesized using click chemistry approach. The structures of all newly synthesized compounds were characterized by FT-IR, 1H and 13C NMR, and MASS spectral data. Most of products demonstrated high antimicrobial activity.
Microwave-assisted synthesis, molecular docking and antimicrobial activity of novel 2-(3-aryl,1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones
Ashok, Dongamanti,Rangu, Kavitha,Hanumantha Rao, Velagapuri,Gundu, Srinivas,Srilata, Ballu,Vijjulatha, Manga
, p. 501 - 514 (2016)
An efficient synthetic protocol of microwave-assisted synthesis of some novel 2-(3-aryl,1-phenyl-1H-pyrazol-4-yl)-8H-pyrano[2,3-f]chromen-4-ones 6a-j in excellent yields starting from 3-(3-aryl,1-phenyl-1H-pyrazol-4-yl)-1-(5-hydroxy-2H-chromen-6-yl)-prope
An uracil-linked hydroxyflavone probe for the recognition of ATP
Bojtár, Márton,Janzsó-Berend, Péter Zoltán,Mester, Dávid,Hessz, Dóra,Kállay, Mihály,Kubinyi, Miklós,Bitter, István
, p. 747 - 755 (2018)
Background: Nucleotides are essential molecules in living systems due to their paramount importance in various physiological processes. In the past years, numerous attempts were made to selectively recognize and detect these analytes, especially ATP using
Synthesis, spectroscopy, X-ray crystallography, DFT calculations, DNA binding and molecular docking of a propargyl arms containing Schiff base
Balakrishnan,Subha,Neelakantan,Mariappan
, p. 671 - 681 (2015)
A propargyl arms containing Schiff base (L) was synthesized by the condensation of 1-[2-hydroxy-4-(prop-2-yn-1-yloxy)phenyl]ethanone with trans-1,2-diaminocyclohexane. The structure of L was characterized by IR, 1H NMR, 13C NMR and U
Synthesis and Antibacterial Evaluation of Benzofuran Based Di-1,2,3-triazoles
Sunitha,Kumar, A. Kishore,Shankaraiah,Jalapathi,Lincoln, Ch. A.
, p. 1515 - 1524 (2018)
A series of novel benzofuran-1,2,3-triazole hybrid molecules are synthesized using the click chemistry approach. Structures of the synthesized compounds were assessed by IR, NMR, and mass spectroscopy. The tests of final products 10a–10l for their antibacterial activity demonstrate excellent to good activity against gram-positive and gram-negative bacteria.
Design and Synthesis of Antimicrobial Active (E)-(3-(Substituted-styryl)-7H-furo[2,3-f]chromen-2-yl)(phenyl)methanone Derivatives and Their In Silico Molecular Docking Studies
Boddupally, Srinivas,Jyothi, Prashanth,Rao, Mandava Venkata Basaveswara,Rao, Koya Prabhakara
, p. 73 - 80 (2019)
Nine new (E)-(3-(substituted-styryl)-7H-furo[2,3-f]chromen-2-yl)(phenyl)methanone derivatives, 7(a–i), with an efficient microwave-assisted synthetic method was achieved by reacting with (E)-3-(aryl)-1-(5-hydroxy-2H-chromen-6-yl)prop-2-en-1-ones and 2-bro
