22288-63-7Relevant academic research and scientific papers
Electro-organic reactions part 35. Efficient carbon-oxygen bond formation in the anodic coupling of pyridopyrimidine derivatives
Gullu, Mustafa,Razack, Liaquat A.,Utley, James H. P.,King, Ronald J.,Ray White
, p. 675 - 684 (2007/10/02)
4-H-Pyrido[1,2-a]pyrimidine-2,4-diones (Chichibabin) derivatives, formed by condensation of 2-aminopyridines with substituted dialkylmalonates, are electroactive. In solution in CH2Cl2/CF3CO2H mixtures they are smoothly and selectively anodically coupled in high yield. The products are novel and unexpected; radical coupling at the C-3 and O-4 positions is involved and the proposed mechanism is analogous to that of oxidative phenolic coupling.
