22304-06-9Relevant academic research and scientific papers
Cleavage and Reassembly of the C═O Bond of 2-Alkynylbenzaldehydes: A Metal-Free Access to Inden-1-ones
Ju, Ying,Liu, Tao,Tan, Jiajing,Yao, Tuanli,Zhang, Feng
, p. 9455 - 9465 (2021/07/26)
A metal-free approach to inden-1-ones from 2-alkynylbenzaldehydes mediated by pyrrolidine has been developed. The reaction proceeds under mild conditions in a step- and atom-economy process by cleaving the C═O bond and constructing new C-C as well as C═O bonds. Oxygen-18 and deuterium labeling experiments revealed an aza-Petasis-Ferrier rearrangement of an intermediate 1-amino-3-methylene-dihydroisobenzofuran.
An unexpected addition of acetic acid to ortho-electron-deficient alkynyl-substituted aryl aldehydes catalyzed by palladium(II) acetate
Zhang, Jianbo,Han, Xiuling
supporting information, p. 2465 - 2470 (2014/09/30)
An unexpected addition of acetic acid to ortho-electron-deficient alkynyl-substituted aryl aldehydes catalyzed by palladium(II) acetate was achieved, which provided a convenient method for the synthesis of dihydroisobenzofurans in moderate to good yields. The electron-withdrawing groups attached to alkynes may play an important role for the cyclization.
