22304-67-2Relevant articles and documents
Photo- and thermochromic spirans 37.*New symmetrical bisspiropyrans of the indoline series
Voloshin,Solov’eva,Bezugliy,Metelitsa,Minkin
, (2012)
New symmetrical bisspiropyrans of the indoline series, which have photochromic properties and are characterized by substantially higher absorption capacity of cyclic isomers in comparison to the monospiropyrans, were obtained on the basis of 4,6-dihydroxy
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle
Wei, Lai,Hou, Tao,Li, Jiaqi,Zhang, Xiuli,Zhou, Han,Wang, Zhenyu,Cheng, Junxiang,Xiang, Kaijing,Wang, Jixia,Zhao, Yaopeng,Liang, Xinmiao
supporting information, p. 2634 - 2647 (2021/04/02)
A series of coumarin-like diacid derivatives were designed and synthesized as novel agonists of human G-protein-coupled receptor 35 (hGPR35). Active compounds were characterized to possess one acidic group on both sides of a fused tricyclic aromatic scaff
Near infrared emission cyanine fluorescent dye capable of being used for detecting physiological viscosity and preparation method thereof
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Paragraph 0027; 0030-0035, (2019/11/22)
Near infrared emission cyanine fluorescent dye capable of being used for detecting physiological viscosity and a preparation method thereof are disclosed. The near infrared emission cyanine fluorescent dye is synthesized by changing a methine chain design in a structure of classical cyanine dye, and a synthesis method is safe and simple. In a pure water system, Stokes displacement exceeds 90 nm, the shortcoming that the Stokes displacement of traditional cyanine dye results in self-quenching is greatly improved, and the maximum emission wavelength (670 nm) is located in a near-infrared regionand is suitable for cell imaging. The fluorescence intensity of the dye is significantly enhanced with increasing viscosity, and the dye has high selectivity and sensitivity to viscosity. In cell imaging experiments, the dye exhibits better water solubility, biocompatibility, and less biotoxicity, can perform targeting positioning on subcellular organelle mitochondria, and detects changes of the viscosity in the mitochondria. In summary, the invention provides a design and synthesis method for novel near-infrared emission cyanine dye which can be used for detecting the physiological viscosity.