223111-68-0Relevant academic research and scientific papers
Synthesis of a new ligand for metal assembly to a selective receptor
Schwabacher, Alan W.,Stefanescu, Andrei D.,Ur Rehman, Atiq
, p. 1784 - 1788 (2007/10/03)
Diarylphosphinic acid 2, bearing two ethylenediamine groups, was designed with the aim of assembly to form a hydrophobic cavity upon binding to metals. The new ligand was prepared in optically active form from phenylalanine by an efficient sequence which required chromatography only for the P-C bond forming steps. Versatile intermediates in the synthesis are described. Complexes of this ligand with Zn2+ were shown to bind closely related aromatic guests bearing anionic tethered groups with 1000-fold discrimination. Diarylphosphinic acid 2, bearing two ethylenediamine groups, was designed with the aim of assembly to form a hydrophobic cavity upon binding to metals. The new ligand was prepared in optically active form from phenylalanine by an efficient sequence which required chromatography only for the P-C bond forming steps. Versatile intermediates in the synthesis are described. Complexes of this ligand with Zn2+ were shown to bind closely related aromatic guests bearing anionic tethered groups with 1000-fold discrimination.
