22312-83-0

Upstream product

• 118-92-3 anthranilic acid 
• 95-51-2 o-chloroaniline 
• 14422-49-2 2-chloroacetamidobenzoic acid 

Downstream Products

• 952613-28-4 3-(2-chloro-phenyl)-2-(4-methyl-2-phenylamino-thiazol-5-yl)-3H-quinazolin-4-one 
• 952613-30-8 3-(2-chloro-phenyl)-2-[2-(4-chloro-phenylamino)-4-methyl-thiazol-5-yl]-3H-quinazolin-4-one 
• 952613-46-6 3-(2-chloro-phenyl)-2-[2-(4-chloro-phenylamino)-4-phenyl-thiazol-5-yl]-3H-quinazolin-4-one 
• 1333248-23-9 3-(2-chlorophenyl)-2-((4-(furan-2-carbonyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one 
• 952614-29-8 3-(2-chlorophenyl)-2-(5-(morpholin-4-yl)-4-(pyridin-4-yl)thiophen-2-yl)-3H-quinazolin-4-one 
• 146071-30-9 2-(2-Butoxy-ethoxymethyl)-3-(2-chloro-phenyl)-3H-quinazolin-4-one 
• 146071-28-5 3-(2-Chloro-phenyl)-2-(2-methoxy-ethoxymethyl)-3H-quinazolin-4-one 
• 146071-40-1 3-(2-Chloro-phenyl)-2-(2-dimethylamino-ethoxymethyl)-3H-quinazolin-4-one 
• 146071-29-6 3-(2-Chloro-phenyl)-2-(2-ethoxy-ethoxymethyl)-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors

Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthes

Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-k{cyrillic}B and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer ag

In an attempt to discover novel inhibitors of NF-κB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs

Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents

A series of 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives were designed and synthesized. Synthesized molecules were further evaluated for their inhibitory activity towards transcription factors NF-κB and AP-1 mediated transcr

THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS

Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

Synthesis and fungicidal activity of 3-aryl-2-(4'-aryl thiazol-2'-ylaminomethyl)quinazol-4(3H)-ones

A series of 3-aryl-2-(4'-aryl thiazol-2'-ylaminomethyl)quinazol-4(3H)-ones 3a-p have been prepared by condensing 3-aryl-2-chloromethylquinazol-4(3H)-ones with 2-amino-4-substituted phenylthiazoles. Another group of 3-aryl-6,8-dibromo-2-(4'-arylthiazol-2'-