223127-24-0

Basic information

• Product Name: 6-(4-Fluorophenyl)-nicotinic acid
• Synonyms: 6-(4-fluorophenyl)-3-Pyridinecarboxylic acid
• CAS NO: 223127-24-0
• Molecular Formula: C₁₂H₈FNO₂
• Molecular Weight: 217.2
• Mol File: 223127-24-0.mol

Chemical Properties

• Boiling Point: 384.5±32.0 °C(Predicted)
• Appearance: /
• Density: 1.318±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.14±0.10(Predicted)
• CAS DataBase Reference: 6-(4-Fluorophenyl)-nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-Fluorophenyl)-nicotinic acid(223127-24-0)
• EPA Substance Registry System: 6-(4-Fluorophenyl)-nicotinic acid(223127-24-0)

Safety Data

• Hazardous Substances Data: 223127-24-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Fluorophenyl)-nicotinic acid is used as a reactant for the design and synthesis of substituted quinolines. These quinolines serve as novel and selective melanin-containing hormone receptor antagonists, which have potential applications as anti-obesity agents. The compound's structural features allow for the development of targeted therapies that can help address obesity-related health issues by modulating specific receptor activities.

Upstream product

• 149500-84-5 methyl 6-(4-fluorophenyl)nicotinate 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 1765-93-1 4-fluoroboronic acid 
• 73781-91-6 6-Chloronicotinic acid methyl ester 
• 26218-78-0 methyl 6-bromonicotinate 

Downstream Products

• 913182-58-8 8-({[6-(4-fluoro-phenyl)-pyridine-3-carbonyl]-amino}-methyl)-quinoline-3-carboxylic acid ethyl ester 
• 925242-79-1 N-(6-dimethylaminomethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-6-(4-fluoro-phenyl)-N-methyl-nicotinamide 
• 925243-16-9 N-(6-chloromethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-6-(4-fluoro-phenyl)-N-methyl-nicotinamide 
• 223125-56-2 ethyl 3-[4-[2-[2-(4-fluorophenyl)pyridine-5-carbonylamino]ethoxy]phenyl]-2-(4-isopropylphenoxy)propionate 
• 521070-56-4 6-(4-fluorophenyl)-N-[3-(1-pyrrolidinylmethyl)-7-quinolinyl]nicotinamide 

Relevant articles and documents

IMIDAZOPYRIDINE DERIVATIVES

The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

MUSCARINIC AGONISTS

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

Amidocarboxylic acid derivatives

Amidocarboxylic acid derivatives of the formula: wherein R1 represents a hydrogen atom, etc.; R2 represents an alkylene group; R3 represents a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; X represents a substituted or unsubstituted aryl group, etc.,; Y represents an oxygen atom, etc.; Z represents an alkylene group, etc.; and W represents an alkyl group, etc.; and pharmacologically acceptable salts thereof and pharmacologically acceptable esters thereof are useful as the active ingredient of pharmaceutical compositions. They may be used to treat specified diseases, including diabetes mellitus, hyperlipemia, arteriosclerosis, hypertension, etc.

N-acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.