22316-46-7

Upstream product

• 22316-45-6 ethyl 2-(N-(5-chloro-2-nitrophenyl)-N-phenylamino)formylacetate 
• 25781-92-4 5-chloro-2-nitro-N-phenylaniline 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 120803-25-0 clobazam-d3 
• 22316-55-8 N-desmethylclobazam 

Relevant academic research and scientific papers

SYNTHESIS AND BIOLOGICAL EVALUATION OF 7-CHLORO-1-TRIDEUTERIOMETHYL-5-PHENYL-1H-1,5-BENZODIAZEPINE-2,4(3H,5H)-DIONE (CLOBAZAM-D3)

Clobazam-d3 has been prepared by treatment of norclobazam sodium salt with trideuteriomethyl iodide.Clobazam-d3 has a pharmacological profile rather similar to that of clobazam.It differs by its longer duration of anti-epileptic action.Keywords - anti-epiliptic action / clobazam-d3

1,5-Benzodiazepine-2,4-diones

This invention relates to substituted 1,5-benzodiazepines having the formula SPC1 Wherein R1 and R2 are hydrogen or substituents, R3 is hydrogen or substituents, R4 is methyl or aryl group, As well as the process of producing the same. The compounds of the invention are tranquillizing analgesic, antipyretic and anti-inflammatory agents.