SYNTHESIS AND BIOLOGICAL EVALUATION OF 7-CHLORO-1-TRIDEUTERIOMETHYL-5-PHENYL-1H-1,5-BENZODIAZEPINE-2,4(3H,5H)-DIONE (CLOBAZAM-D3)

DOI: 10.1016/0223-5234(88)90137-7

Source and publish data:

European Journal of Medicinal Chemistry p. 417 - 420 (1988)

Update date:2022-07-30

Topics:

Authors:

Poupaert, Jacques H.

Guiot, Pierre

Jacqmin, Philippe

Dumont, Pierre

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Article abstract of DOI:10.1016/0223-5234(88)90137-7

Clobazam-d3 has been prepared by treatment of norclobazam sodium salt with trideuteriomethyl iodide.Clobazam-d3 has a pharmacological profile rather similar to that of clobazam.It differs by its longer duration of anti-epileptic action.Keywords - anti-epiliptic action / clobazam-d3

Full text of DOI:10.1016/0223-5234(88)90137-7

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