22324-11-4

Upstream product

• 405555-12-6 N-[4-(2-{6,7-dimethoxy-1-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-methyl-2-oxo-ethylsulfamoyl)-phenyl]-2,2,2-trifluoro-acetamide 
• 50-00-0 formaldehyd 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 90-50-6 3,4,5-trimethoxycinnamic acid 
• 692717-17-2 6,7-dimethoxy-1-[2-(3,4,5-trimethoxyphenyl)ethyl]-3,4-dihydroisoquinoline 
• 20947-58-4 N-(3,4-Dimethoxy-phenaethyl)-3-(3,4,5-trimethoxy-phenyl)-propionsaeureamid 
• 3840-30-0 5-(chloromethyl)-1,2,3-trimethoxybenzene 
• 108683-61-0 triphenyl(3,4,5-trimethoxybenzyl)phosphonium chloride 
• 61381-12-2 methyl <(2S,3R)-dihydroxy-3-(6',7'-dimethoxy-1',2',3',4'-tetrahydroisoquinolin-1'(R)-yl)>propanoate hydrochloride 
• 111623-23-5 (R)-6,7-Dimethoxy-1-((1R,2S)-2-methoxycarbonyl-1,2-bis-methoxycarbonyloxy-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid methyl ester 
• 111623-29-1 (S)-6,7-Dimethoxy-1-[(E)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid methyl ester 
• 111623-25-7 methyl <(2S,3R)-dihydroxy-3-(N-methoxycarbonyl-6',7'-dimethoxy-1',2',3',4'-tetrahydroisoquinolin-1'-(R)-yl)>propanoate 
• 111623-21-3 (R)-2-methoxycarbonyl-1-formyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 405555-10-4 4-amino-N-(2-{6,7-dimethoxy-1-[2-oxo-2-(3,4,5-trimethoxy-phenyl)-ethyl]-3,4-dihydro-1H-isoquinolin-2-yl}-1-methyl-2-oxo-ethyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Biomimetic Total Synthesis of Dysoxylum Alkaloids

A five-step total synthesis of Dysoxylum alkaloids has been achieved using a biomimetic approach from zanthoxylamide protoalkaloids. The synthesis featured a direct amidation and a Bischler-Napieralski reaction to form the dihydroisoquinoline ring, which

Enantioselective synthesis of some tetracyclic isoquinoline alkaloids by asymmetric transfer hydrogenation catalysed by a chiral ruthenium complex

Asymmetric transfer hydrogenation catalysed by chiral ruthenium complexes was the method for enantioselective synthesis of (R)-(+)-coralydine, (S)-(-)-homoprotoberberine, and (S)-(+)-homoaporphine in fair to excellent enantiomeric purity. Springer-Verlag 2005.

The synthesis of isoquinoline alkaloid and its related compounds using alanine derivatives as chiral auxiliaries.

Chiral 1-substituted isoquinoline derivatives, which were obtained by the reaction using alanine derivatives as chiral auxiliaries, were transformed to (S)-2,3,9,10,11-pentamethoxyhomoprotoberberine (7) and a synthetic intermediate for O-methylkreysigine

Enantioselective synthesis of (S)-2,3,9,10,11-penta- methoxyhomoprotoberberine and (S)-O-methyl-kreysigine using an asymmetric addition to an isoquinoline ring

Total synthesis of (S)-2,3,9,10,11-pentamethoxyhomoprotoberberine (7) was carried out using an asymmetric nucleophilic addition of a silyl enol ether to 5,8-dibromo-6,7-dimethoxyisoquinoline (1) in the presence of an acid chloride derived from alanine. Th