223252-57-1Relevant academic research and scientific papers
Vinyl isonitriles in radical cascade reactions: Formation of cyclopenta-fused pyridines and pyrazines
Lenoir, Isabelle,Smith, Marie L.
, p. 641 - 643 (2000)
The formation of cyclopenta-fused pyridines and pyrazines were studied by using radical cascade reactions. The intramolecular addition to an aryl or vinyl isonitrile combined with intramolecular trapping of the intermediate imidoyl radical was also investigated for the synthesis of biologically active natural products. It was shown that the vinyl isonitriles were required substrates in 4 + 1 radical annulations with iodoalkynes and iodonitriles for the formation of cyclopenta-fused pyridines and pyrazines respectively.
Multicomponent synthesis of novel amino acid-nucleobase chimeras: aA versatile approach to PNA-monomers
Maison, Wolfgang,Schlemminger, Imre,Westerhoff, Ole,Martens, Juergen
, p. 1343 - 1360 (2007/10/03)
This paper describes a multicomponent approach to novel totally protected precursors of PNA-monomers via Ugi 4CC. The obtained bisamides are converted into several partially protected PNA-monomers or derivatives thereof using three different procedures. Methods for hydrolysis are shown to be dependent on the nature of the isocyano component required for Ugi 4CC. Several novel monomers suitable for oligomer synthesis are prepared demonstrating the high versatility of the reaction sequence. Copyright (C) 2000 Elsevier Science Ltd.
