1263086-89-0Relevant academic research and scientific papers
Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines
Xu, Zhigang,Dietrich, Justin,Shaw, Arthur Y.,Hulme, Christopher
experimental part, p. 4566 - 4569 (2010/09/18)
A two-step solution phase synthesis employing a double UDC (Ugi/Deprotect/Cyclize) strategy has been utilized to obtain fused 6,7,6,6-quinoxalinone-benzodiazepines and 6,7,7,6-bis-benzodiazepines. Optimization of the methodology to produce these tetracyclic scaffolds was enabled by microwave irradiation, incorporation of trifluoroethanol as solvent, and the use of the convertible isocyanide, 4-tert-butyl cyclohexen-1-yl isocyanide.
