223253-74-5

Upstream product

• 5470-11-1 hydroxylamine hydrochloride 
• 223253-70-1 [4-(2-isopropoxy-phenyl)-piperazin-1-yl]-acetaldehyde 

Relevant academic research and scientific papers

Heterocycles useful in the treatment of benign prostatic hyperplasia

This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.