223378-20-9Relevant academic research and scientific papers
Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities
Kitano, Kenji,Machida, Haruhiko,Miura, Shinji,Ohrui, Hiroshi
, p. 827 - 830 (1999)
Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'- deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.
