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Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities

DOI: 10.1016/S0960-894X(99)00090-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 827 - 830 (1999)

Update date:2022-08-04

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Authors:

Kitano, KenjiKitano, Kenji

Machida, HaruhikoMachida, Haruhiko

Miura, ShinjiMiura, Shinji

Ohrui, HiroshiOhrui, Hiroshi

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Article abstract of DOI:10.1016/S0960-894X(99)00090-6

Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'- deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.

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Full text of DOI:10.1016/S0960-894X(99)00090-6

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Product name:1-((2R,3R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-3-hydroxy-5-methyl-tetrahydro-furan-2-yl)-5-((E)-2-bromo-vinyl)-1H-pyrimidine-2,4-dione

Cas No:223378-20-9

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