Bioorganic and Medicinal Chemistry Letters p. 827 - 830 (1999)
Update date:2022-08-04
Topics:
Kitano, Kenji
Machida, Haruhiko
Miura, Shinji
Ohrui, Hiroshi
Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'- deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.
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Doi:10.1016/S0040-4039(01)90802-0
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