Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities

DOI: 10.1016/S0960-894X(99)00090-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 827 - 830 (1999)

Update date:2022-08-04

Topics:

Authors:

Kitano, Kenji

Machida, Haruhiko

Miura, Shinji

Ohrui, Hiroshi

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Article abstract of DOI:10.1016/S0960-894X(99)00090-6

Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'- deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.

Full text of DOI:10.1016/S0960-894X(99)00090-6

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