223383-68-4Relevant academic research and scientific papers
Catalytic transfer hydrogenation of ketones by the use of ruthenium complexes incorporating the new tridentate ligand, bis(2-oxazolin-2-ylmethyl)phenylphosphine
Braunstein, Pierre,Fryzuk, Michael D.,Naud, Frederic,Rettig, Steven J.
, p. 589 - 594 (2007/10/03)
The new heterofunctional phosphine ligand bis(2-oxazolin-2-ylmethyl)phenylphosphine (N,P,N) has been prepared and has allowed the synthesis of the ruthenium complexes fac-[RuCl2(DMSO)(N,P,N)] 1, fac-[RuCl2(PPh3)(N,P,N)] 2, [RuCl(η6-C6H6)(N,P,N)][O 3SCF3] 3 and [Ru(η6-C6H6)(N,P,N)][O3SCF 3]2 4. When tridentate, as in 1, 2, and 4, this ligand co-ordinates in a facial-type mode. In complex 3, it acts as a P,N-chelate with a dangling oxazoline ring. The structures of the ligand, 2·CH2Cl2·0.25C6H14 and 3 have been determined by X-ray diffraction. Complexes 1-4 catalyse the transfer hydrogenation reaction between propan-2-ol and ketones. Only small differences in reactivity were observed between 3 and 4, despite the different ligand bonding mode in these complexes. For the best catalyst, 2, yields up to 97% were obtained and turnover frequencies may be as high as 112 000 h-1.
