223392-77-6Relevant academic research and scientific papers
A clean synthesis of 2,5-dihydro-1H-pyrrole-2-carboxylates under catalyst-free and solvent-free conditions: cytotoxicity and molecular docking studies
Niknam, Khodabakhsh,Bavadi, Masoumeh,Mojikhalifeh, Sanaz,Shahraki, Omolbanin
, p. 1613 - 1623 (2018)
Abstract: A concise, clean synthetic approach to access of 2,5-dihydro-1H-pyrrole-2-carboxylates by two-component condensation reaction of ethyl pyruvate and aniline derivatives under catalyst-free and solvent-free conditions is described. The advantages of this method are practical simplicity, catalyst-free and solvent-free conditions, high atom economy, short reaction times, and good yields of the products. The anticancer potential of synthesized compounds was evaluated against MCF7, MOLT-4 and HL-60 cells by using MTT assay. Among the tested synthesized 2,5-dihydro-1H-pyrrole-2-carboxylates (3a-h, 4a-d), compound 4d having sulfonamide moiety exhibited good cytotoxic activity against all tested cell lines and molecular docking studies also demonstrated that the results of the docking study are in reasonable agreement with cytotoxicity activities. Graphical Abstract: A series of 2,5-dihydro-1H-pyrrole-2-carboxylate derivatives were synthesized by two-component condensation reaction of ethyl pyruvate and aniline derivatives under catalyst-free and solvent-free conditions.[Figure not available: see fulltext.].
Method for catalytic synthesis of 3-pyrroline-2-one in emulsion by synergizing titanocene dichloride with Bronsted acid
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Paragraph 0016; 0017; 0018; 0019; 0028; 0029; 0030; 0031, (2019/02/04)
The invention discloses a method for catalytic synthesis of 3-pyrroline-2-one in the emulsion by synergizing titanocene dichloride with Bronsted acid. According to the method, a emulsion system is constructed by taking the titanocene dichloride and Bronst
A robust synthesis and characterization of superparamagnetic CoFe2O4 nanoparticles as an efficient and reusable catalyst for green synthesis of some heterocyclic rings
Aleem Ali El-Remaily, Mahmoud Abd El,Abu-Dief, Ahmed M.,El-Khatib, Rafat M.
, p. 1022 - 1029 (2016/11/23)
A robust synthesis for magnetic CoFe2O4 nanoparticles via a hydrothermal technique was investigated. The prepared magnetic nanoparticles were characterized using powder X-ray diffraction, scanning, transmission and high-resolution tr
Synthesis and Reaction with Oxalyl Chloride of Ethyl 1-Aryl-4,5-dioxo-2-pyrrolidinecarboxylates and Their 3-Arylamino Derivatives
Gein,Shumilovskikh,Voronina,Gein,Khokhryakova,Tendryakova,Vyaznikova,Andreichikov
, p. 1267 - 1270 (2007/10/03)
Ethyl piruvate was reacted with aromatic amines to obtain ethyl 1-aryl-4-arylamino-2-methyl-5-oxo-2,5-dihydropyrrol-1H-2-pyrrolecarboxylates. Hydrolysis of the latter with hydrochloric acid gave ethyl 1-aryl-2-methyl-4,5-dioxo-2-pyrrolidinecarboxylates. Oxalyl chloride reacts with the 4-arylamino derivatives to give ethyl 1,5-diaryl-4-methyl-2,3,6-dioxo-1,2,3,4,5,6-hexahydropyrrolo[3,4-b]pyrrole-4- carboxylates, and the reaction with 1-aryl-2-methyl-4,5-dioxo-2-pyrrolidinecarboxylates yields 1-aryl-1-(ethoxycarbonyl)-5-methyl-2-oxo-2,5-dihydro-1H-3-pyrrolyl) oxalates.
