223409-31-2

Upstream product

• 93-97-0 benzoic acid anhydride 
• 223409-19-6 N⁶-benzoyl-9-(2-tert-butoxycarbonylethyl)adenine 
• 183181-61-5 N⁶-benzoyl-9-(2-carboxyethyl)adenine 
• 223409-15-2 9-(2-tert-butoxycarbonylethyl)adenine 
• 98-88-4 benzoyl chloride 
• 223409-28-7 N⁶-benzoyl-9-(4-ethoxycarbonyl-3-oxobutyl)adenine 

Downstream Products

• 223409-35-6 N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-4-ethoxycarbonylbutyl>adenine 
• 223409-46-9 [6-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-hex-1-enyl]-phosphonic acid diisopropyl ester 
• 223409-52-7 N⁶-benzoyl-9-(3-hydroxy-6-diisopropylphosphono-5-hexenyl)-adenine 
• 223409-40-3 N⁶-benzoyl-9-<3-(tert-butyldimethylsilyloxy)-5-oxopentyl>adenine 

Relevant academic research and scientific papers

Synthesis of acyclic carba-nucleoside phosphonates, structural analogues to natural deoxyribonucleotides

Acyclic carba-nucleoside phosphonates, modelled on natural deoxyribonucleotides have been prepared starting from DNA nucleobases and tert-butyl acrylate. The products obtained from a Michael-type reaction were elongated to β-oxo esters that were first reduced to β-hydroxy esters and then transformed into protected β-hydroxy aldehydes. Wittig-Homer-Emmons reaction with the anion of tetraisopropyl methylenebisphosphonate gave, after deprotection, the desired 4-hydroxy-6-purinyl- or -6-pyrimidinyl-1- hexenylphosphonic acids. A dimer, potential precursor of acyctic polynucleotides (APN), homomorphous with DNA, was also prepared.