223418-94-8

Upstream product

• 94742-46-8 2-trimethylsilyl-3-chloromethyl furane 

Downstream Products

• 204063-30-9 methyl (E)-4-oxo-2-<2-(2,6,6-trimethylcyclohex-1-enyl)ethyl>but-2-enoate 
• 101822-33-7 5-Hydroxy-3-[2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-5H-furan-2-one 
• 128292-90-0 methyl (Z,E)-4-oxo-2-<2-(2,6,6-trimethylcyclohex-1-enyl)vinyl>but-2-enoate 
• 204063-24-1 5-Hydroxy-3-[2-(toluene-4-sulfonyl)-2-(2,6,6-trimethyl-cyclohex-1-enyl)-ethyl]-5H-furan-2-one 
• 101822-26-8 3-<2-(2,6,6-trimethylcyclohex-1-enyl)ethyl>-2-trimethylsilylfuran 

Relevant academic research and scientific papers

The inhibitory mechanism of bovine pancreatic phospholipase A2 by aldehyde terpenoids

We established the stereoselective synthesis of (E)-3-methoxycarbonyl- 2,4,6-trienal compound A and discovered that the compound A showed more powerful inhibitory activity toward phospholipase A2(PLA2) from bovine pancreas than manoalide which is a typical PLA2 inhibitor. As the inhibitory mechanism of PLA2 by A, the irreversible formation of dihydropyridine derivative resulting from the reaction of A with lysine residues in PLA2 was proposed based on the model reactions. Furthermore, A was found to selectively modify Lys56 which is included in the interfacial recognition site of this enzyme by the MALDI-TOF-MS peptide mapping analyses.