22342-46-7

Basic information

• Product Name: (2S,3S,4R)-CIS-5-(3,4-DIAMINOTETRAHYDRO-2-THIENYL)VALERIC ACID
• Synonyms: (2S,3S,4R)-CIS-5-(3,4-DIAMINOTETRAHYDRO-2-THIENYL)VALERIC ACID;CIS-3,4-DIAMINO-2-TETRAHYDROTHIOPHENEVALERIC ACID;DIAMINOBIOTIN;cis-3,4-Diamino-2-tetrahydrothiophenevaleric acid, (2S,3S,4R)-cis-5-(3,4-Diaminotetrahydro-2-thienyl)valeric acid;3,4-Diaminotetrahydro-2-thiophenevaleric acid;Tetrahydro-3,4-diamino-2-thiophenepentanoic acid;(2S,3S,4R)-;5-((2S,3S,4R)-3,4-diaminotetrahydrothiophen-2-yl)pentanoic acid
• CAS NO: 22342-46-7
• Molecular Formula: C₉H₁₈N₂O₂S
• Molecular Weight: 291.24
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 22342-46-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: H2O: 20 mg/mL, clear, colorless
• Stability: Hygroscopic
• CAS DataBase Reference: (2S,3S,4R)-CIS-5-(3,4-DIAMINOTETRAHYDRO-2-THIENYL)VALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,4R)-CIS-5-(3,4-DIAMINOTETRAHYDRO-2-THIENYL)VALERIC ACID(22342-46-7)
• EPA Substance Registry System: (2S,3S,4R)-CIS-5-(3,4-DIAMINOTETRAHYDRO-2-THIENYL)VALERIC ACID(22342-46-7)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 22342-46-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Blue Solid

Uses

Biotin (B389040) impurity.

Upstream product

• 33607-60-2 (3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid 

Downstream Products

• 58-85-5 biotin 
• 13395-35-2 5-((3aS)-2-amino-(3ar,6ac)-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4t-yl)-valeric acid 
• 58-85-5 (+/-)-5-(2-oxo-(3ar,6at)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid 
• 58-85-5 (+/-)-biotin 

Relevant articles and documents

A benzyl biological the element escapes the animal pen method for preparing biotin

The invention belongs to the technical field of fine chemical engineering, and discloses a method for preparing biotin by debenzylating benzyl biotin. The method comprises the following steps: fully dispersing dibenzyl biotin synthesized through different processes in hydrobromic acid under the assistance of a dispersant, rapidly stirring, carrying out heating distillation, condensing and layering steamed benzyl bromide and hydrobromic acid, refluxing the upper layer hydrobromic acid to a reaction solution, separating out the lower layer benzyl bromide, rapidly cooling, carrying out vacuum distillation to recover hydrobromic acid, adding a quantitative of water or a mother liquor to the above obtained residual solid, carrying out heating dissolving, adjusting the acidity, adding active carbon for decoloring, cooling for precipitating biotin crystals (87% of a theoretic amount), carrying out drying and distillation purification of benzyl bromide to obtain qualified benzyl bromide, crystallizing open ring substances residual in the mother liquor, continuously indiscriminately using the mother liquor 20 times, controlling the pH value by a liquid alkali, and carrying out ring closure of triphosgene to obtain recovered biotin. The yield of biotin is averagely improved by 5% in the invention. The method has the advantages of safety, environmental protection, high yield, good quality, low cost, and suitableness for industrialized production.