223433-53-2

Basic information

• Product Name: tert-butyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-piperidin-1-ylbutanoate
• CAS NO: 223433-53-2
• Molecular Formula: C₁₉H₃₃NO₃
• Molecular Weight: 323.4702
• Mol File: 223433-53-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 454.229°C at 760 mmHg
• Flash Point: 228.51°C
• Density: 1.034g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: tert-butyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-piperidin-1-ylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-piperidin-1-ylbutanoate(223433-53-2)
• EPA Substance Registry System: tert-butyl (3R)-3-(cyclopentylmethyl)-4-oxo-4-piperidin-1-ylbutanoate(223433-53-2)

Safety Data

• Hazardous Substances Data: 223433-53-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 204637-77-4 (R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester 

Downstream Products

• 174265-38-4 cipemastat 

Relevant articles and documents

Practical approaches to the matrix metalloproteinase inhibitor Trocade (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315

Stereoselective methods were found to efficiently prepare 2- and 3-substituted succinates with anti configuration. In the synthesis of Trocade 1, the hydantoinmethyl residue was introduced by alkylation of the non-chelated potassium enolate 19 with the br