174265-38-4

Usage

Uses

Cartilage protec- tive agent in rheumatoid arthritis.

Upstream product

• 306273-04-1 (2S,3R)-3-Cyclopentylmethyl-4-oxo-4-piperidin-1-yl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-butyric acid tert-butyl ester 
• 204637-81-0 (R)-2-Benzyloxycarbonyl-3-cyclopentylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester 
• 204637-78-5 (2S,3R)-2-Cyclopentylmethyl-3-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-tert-butyl ester 
• 159135-61-2 3-bromomethyl-1,5,5-trimethylimidazolidine-2,4-dione 
• 204637-83-2 (R)-3-Benzyloxycarbonyl-3-tert-butoxycarbonyl-2-cyclopentylmethyl-4-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-butyric acid benzyl ester 
• 6851-81-6 1,5,5-trimethylhydantoin 
• 110-89-4 piperidine 
• 223433-53-2 (R)-3-cyclopentylmethyl-4-oxo-4-piperidin-1-yl-butyric acid tert-butyl ester 
• 204637-84-3 1-[2(R)-[1(R)-(tert-butoxycarbonyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 174265-77-1 1-[2(R)-[1(R)-carboxy-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 204637-79-6 (2R,3R)-2-Cyclopentylmethyl-3-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-tert-butyl ester 
• 204637-77-4 (R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester 
• 204637-85-4 1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine 
• 174265-78-2 (2S,3R)-3-Cyclopentylmethyl-4-oxo-4-piperidin-1-yl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-butyric acid 

Relevant academic research and scientific papers

Process for the preparation of hydroxamic acid derivatives

The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.

Practical approaches to the matrix metalloproteinase inhibitor Trocade (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315

Stereoselective methods were found to efficiently prepare 2- and 3-substituted succinates with anti configuration. In the synthesis of Trocade 1, the hydantoinmethyl residue was introduced by alkylation of the non-chelated potassium enolate 19 with the br

Process for the preparation of chiral lactones

The present invention relates to a process for the preparation of compounds of formula I wherein R1and R2are as defined in the specification as well as to the novel intermediates obtained by said process.

Alkylation of succinates: Synthesis of Ro 32-3555

A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.

Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)

A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.