223458-11-5

Upstream product

• 848691-91-8 (Z)-5-(tert-butyldiphenylsilyl)oxy-3-methyl-1-trimethylsilyl-3-penten-1-yne 
• 848691-94-1 (Z)-5-(tert-butyldimethylsilyl)oxy-3-methyl-3-pentenoic acid 
• 360768-07-6 (Z)-3-bromo-5-(tert-butyldiphenylsilyl)oxy-1-trimethylsilyl-3-penten-1-yne 
• 858917-40-5 ethyl (Z)-5-((tert-butyldimethylsilyl)oxy)-3-methylpent-2-enoate 
• 858918-41-9 1-[(2Z)-3-methyl-5-(1,1,2,2-tetramethyl-1-silapropoxy)pent-2-enyloxy]-2,2-dimethyl-1,1-diphenyl-1-silapropane 
• 848691-95-2 methyl (Z)-5-(tert-butyldimethylsilyl)oxy-3-methyl-3-pentenoate 
• 86462-83-1 (Z)-5-(tert-butyldimethylsilyloxy)-3-methylpent-2-en-1-ol 

Downstream Products

• 848691-92-9 (Z)-5-(tert-butyldimethylsilyl)oxy-3-methyl-3-penten-1-al 
• 856410-37-2 (2E,5Z)-(1R)-7-(tert-butyldiphenylsilyl)oxy-1-{(4R,5S)-2,2-dimethyl-5-[2-(4-methoxybenzyloxy)ethyl]-[1,3]-dioxolan-4-yl}-5-methyl-hepta-2,5-dien-1-ol 
• 858916-49-1 [6-(tert-butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-hex-4-enyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Stereoselective preparation of trisubstituted (Z)-alkenes; synthesis of the C17-C27 fragment of (-)-laulimalide

A Ni-catalyzed cross-coupling reaction of (Z)-5-(tert-butyldiphenylsilyl) oxy-3-bromo-1-trimethylsilyl-3-penten-1-yne (1) with alkyl Grignard reagent gives (Z)-3-alkyl-5-(tert-butyldiphenylsilyl)oxy-1-trimethylsilyl-3-penten-1- ynes (2) stereospecifically

Total synthesis of (+)-dactylolide

(Chemical Equation Presented) The development of an approach leading to the total synthesis of dactylolide is described. The key features of this route include a catalytic asymmetric allylation, a diastereoselective pyran annulation, and a Horner-Wadswort