223462-04-2Relevant academic research and scientific papers
Synthesis of new 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol-5- yl)amino] substituted 4(3H)-quinazolinone derivatives with antineoplastic activity
Raffa,Daidone, Giuseppe,Schillaci,Maggio,Plescia
, p. 251 - 254 (2007/10/03)
A novel series of 3-(3-phenyl-isoxazol-5-yl) or 3-[(3-phenyl-isoxazol- 5-yl)amino] substituted 4(3H)-quinazolinone derivatives was synthesized. The compounds were tested for their antineoplastic activity in vitro against Raji (human Burkitt limphoma), K-562 (human chronic myelogeneous leukemia) and U937 (human histiocytic limphoma) cell lines. The most active quinazolinones showed IC50 values in the range 16-30 μM.
