223466-83-9Relevant academic research and scientific papers
Discovery of a new chemical lead for a matrix metalloproteinase inhibitor
Ikura, Masahiro,Nakatani, Shingo,Yamamoto, Shingo,Habashita, Hiromu,Sugiura, Tsuneyuki,Takahashi, Kanji,Ogawa, Koji,Ohno, Hiroyuki,Nakai, Hisao,Toda, Masaaki
, p. 4241 - 4252 (2007/10/03)
A series of N-benzoyl γ-aminobutyric hydroxamic acids were synthesized and evaluated as matrix metalloproteinase inhibitors. First, we focused on chemical modification of the N-benzoyl residue. Introduction of electron-rich para-substituents was effective
Aminobutyric acid derivatives
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, (2008/06/13)
An aminobutyric acid derivative of the formula (I): (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an inhibitory activity on matrix metalloproteinase and are useful for prevention and/or treatment of diseases, for example, rheumatoid diseases, arthrosteitis, unusual bone resorption, osteoporosis, periodontitis, interstitial nephritis, arteriosclerosis, pulmonary emphysema, cirrhosis, cornea injury, metastasis of, invasion of or growth of tumor cells, autoimmune disease (e.g. Crohn's disease, Sjogren's syndrome), disease caused by vascular emigration or infiltration of leukocytes, arterialization, multiple sclerosis, aorta aneurysm, endometriosis.
