223473-03-8Relevant academic research and scientific papers
An easy strategy for the synthesis of 5-phosphorylated pyrimidin-2,4- diones from β-phosphine oxide and phosphonate enamines
Palacios, Francisco,Aparicio, Domitila,Ochoa de Retana, Ana M.,De los Santos, Jesus M.,Garcia, Jesus,Oyarzabal, Julen
, p. 3105 - 3116 (1999)
An easy and efficient synthesis of pyrimidin-2,4-diones substituted with a phosphine oxide or phosphonate group in the 5-position is described. The key step is the cyclization of functionalized amides, with ethyl chloroformate in the presence of base. In
