An easy strategy for the synthesis of 5-phosphorylated pyrimidin-2,4- diones from β-phosphine oxide and phosphonate enamines

Article abstract of DOI:10.1016/S0040-4020(99)00069-1

An easy and efficient synthesis of pyrimidin-2,4-diones substituted with a phosphine oxide or phosphonate group in the 5-position is described. The key step is the cyclization of functionalized amides, with ethyl chloroformate in the presence of base. In