Tetrahedron p. 3105 - 3116 (1999)
Update date:2022-09-26
Topics:
Palacios, Francisco
Aparicio, Domitila
Ochoa de Retana, Ana M.
De los Santos, Jesus M.
Garcia, Jesus
Oyarzabal, Julen
An easy and efficient synthesis of pyrimidin-2,4-diones substituted with a phosphine oxide or phosphonate group in the 5-position is described. The key step is the cyclization of functionalized amides, with ethyl chloroformate in the presence of base. In
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Doi:10.1248/cpb.47.394
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